Best Heartburn Medications: Antacids vs PPIs vs H2 Blockers

Heartburn is a common condition that causes a burning feeling in the chest, usually after eating. It happens when stomach acid flows back up into the esophagus. While occasional heartburn can often be managed with over-the-counter treatments, choosing the right medication can make a big difference in how quickly and effectively you find relief.

At Sylvania Pharmacy, we’re here to help you understand your options. In this guide, we’ll explain the most common types of heartburn medications: antacids, H2 blockers, and proton pump inhibitors (PPIs)—so you can make an informed decision.

What Causes Heartburn?

Heartburn is often triggered by:

• Eating large or fatty meals

• Lying down after eating

• Spicy or acidic foods

• Smoking

• Stress

• Certain medications (like NSAIDs)

Over time, frequent heartburn may be a sign of a condition called gastroesophageal reflux disease (GERD), which may require longer-term treatment.

Types of Heartburn Medications

Let’s take a closer look at the three main types of over-the-counter and prescription medications used to treat heartburn:

1. Antacids – Fast Relief

Antacids provide quick, short-term relief by neutralizing stomach acid.

Common Brands:

• Tums®

• Rolaids®

• Mylanta®

• Gaviscon®

How They Work:
Antacids act quickly (within minutes) by directly buffering the acid in your stomach. They are great for mild, occasional heartburn.

Best For:

• People with infrequent heartburn

• Those who need fast relief after a meal

Considerations:

• Effects wear off quickly

• Not meant for long-term use

• May cause constipation or diarrhea depending on the ingredients (calcium, magnesium, or aluminum)

2. H2 Blockers – Longer-Lasting Relief

H2 blockers reduce the amount of acid your stomach makes.

Common Brands:

• Pepcid® (famotidine)

• Tagamet® (cimetidine)

• Zantac 360® (famotidine)

How They Work:
These medications block histamine receptors in the stomach lining, which helps reduce acid production. They take longer to start working than antacids (usually 30 to 60 minutes) but can provide relief for up to 12 hours.

Best For:

• People who get heartburn more than twice a week

• Nighttime heartburn

• Preventing heartburn when taken before a meal

Considerations:

• May interact with other medications

• Long-term use should be discussed with a healthcare provider

3. Proton Pump Inhibitors (PPIs) – Strongest Option

PPIs are the most powerful acid reducers and are used for frequent or severe heartburn.

Common Brands:

• Prilosec OTC® (omeprazole)

• Nexium® (esomeprazole)

• Prevacid® (lansoprazole)

How They Work:
PPIs block the proton pumps in the stomach lining that produce acid. They don’t provide immediate relief but work best when taken daily for ongoing symptoms. Full effect may take 1–4 days.

Best For:

• Frequent heartburn (2 or more days a week)

• GERD

• Stomach ulcers

Considerations:

• Best taken before the first meal of the day

• Not meant for instant relief

• Should be used short-term (usually 14 days) unless prescribed

• Long-term use may lead to vitamin deficiencies or bone issues

Which Medication Is Right for You?

The right heartburn medication depends on how often and how severe your symptoms are.

If you’re unsure which product to try, the pharmacists at Sylvania Pharmacy are happy to help guide you based on your health needs.

Tips to Prevent Heartburn Naturally

In addition to medication, try these simple tips:

• Eat smaller meals more frequently

• Avoid trigger foods (spicy, fried, acidic)

• Don’t lie down after eating—wait at least 2–3 hours

• Raise the head of your bed if you get heartburn at night

• Quit smoking, as it weakens the esophageal sphincter

• Maintain a healthy weight, which reduces pressure on the stomach

When to Talk to Your Doctor

You should see your doctor if:

• You need to use heartburn medication regularly for more than 2 weeks

• Symptoms wake you at night

• You have trouble swallowing

• You experience unexplained weight loss

• Over-the-counter treatments are not working

Persistent heartburn may be a sign of a more serious issue, such as GERD or a stomach ulcer.

Final Thoughts from Sylvania Pharmacy

Heartburn is common, but it doesn’t have to control your life. Whether you need fast relief after a spicy meal or longer-term protection from frequent symptoms, there’s a treatment that can help.

At Sylvania Pharmacy, our pharmacists are here to answer your questions and help you choose the right medication for your needs. Visit us today or call to speak with one of our knowledgeable team members.